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The active substance in Viramunenevirapineis a non-nucleoside reverse-transcriptase inhibitorNNRTIIt blocks the activity of reverse transcriptasean enzyme produced by HIV-1 that allows it to infect cells in the body and make more virusesBy blocking this enzymeViramunetaken in combination with other antiviral medicinesreduces the amount of HIV-1 in the blood and keeps it at a low levelViramune does not cure HIV-1 infection or AIDSbut it may delay the damage to the immune system and the development of infections and diseases associated with AIDS.

Indicated for treatment of HIV-1 infection in combination with other antiretrovirals.

In the multinational 2NN studya population pharmacokinetic substudy of 1,077 patients was performed that included 391 femalesFemale patients showed a 13.8lower clearance of nevirapine than did male patientsThis difference is not considered clinically relevantSince neither body weight nor Body Mass IndexBMIhad influence on the clearance of nevirapinethe effect of gender cannot be explained by body sizeNevirapine pharmacokinetics in HIV-1 infected adults does not appear to change with agerange 19-68 yearsor raceBlackHispanicor CaucasianNevirapine has not been specifically investigated in patients over the age of 65.

Discontinue immediately with signs or symptoms of hepatitis or increased transaminase levels combined with rash or other systemic symptoms.

LactoseViramune tablets contain 636 mg of lactose per maximum recommended daily dose.

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