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Antidepressant medications are used to treat a variety of conditionsincluding depression and other mental/mood disordersThese medications can help prevent suicidal thoughts/attempts and provide other important benefitsHoweverstudies have shown that a small number of peopleespecially people younger than 25who take antidepressants for any condition may experience worsening depressionother mental/mood symptomsor suicidal thoughts/attemptsThereforeit is very important to talk with the doctor about the risks and benefits of antidepressant medicationespecially for people younger than 25even if treatment is not for a mental/mood condition.

Patients should be advised to take SARAFEM exactly as prescribedand to continue taking SARAFEM as prescribed even after their symptoms improvePatients should be advised that they should not alter their dosing regimenor stop taking SARAFEM without consulting their physiciansee WARNINGS AND PRECAUTIONSPatients should be advised to consult with their healthcare provider if their symptoms do not improve with SARAFEM.

Signs and symptoms of hyponatremia include headachedifficulty concentratingmemory impairmentconfusionweaknessand unsteadinesswhich may lead to fallsMore severe and/or acute cases have been associated with hallucinationsyncopeseizurecomarespiratory arrestand death.

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In 2 studiespreviously stable plasma levels of imipramine and desipramine have increased greater than 2to 10-fold when fluoxetine has been administered in combinationThis influence may persist for 3 weeks or longer after fluoxetine is discontinuedThusthe dose of TCAs may need to be reduced and plasma TCA concentrations may need to be monitored temporarily when fluoxetine is coadministered or has been recently discontinuedsee CLINICAL PHARMACOLOGY

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